Mount Sinai School of Medicine | , the mesocorticolimbic system and extended amygdala as drugs of abuse Volkow et al, 2004 |
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Further, viral overexpression of delta FosB enhances the conditioned place preference for an environment paired with sexual experience Hedges et al | Substance-use disorder: A diagnostic term in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders DSM-5 referring to recurrent use of alcohol or other drugs that causes clinically and functionally significant impairment, such as health problems, disability, and failure to meet major responsibilities at work, school, or home |
Functional neuroimaging studies in humans have shown that gambling Breiter et al, 2001 , shopping Knutson et al, 2007 , orgasm Komisaruk et al, 2004 , playing video games Koepp et al, 1998; Hoeft et al, 2008 and the sight of appetizing food Wang et al, 2004a activate many of the same brain regions i.
25"Chapter 15: Reinforcement and Addictive Disorders" | "The disease of addiction: origins, treatment, and recovery" |
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In humans, the role of dopamine signaling in incentive-sensitization processes has recently been highlighted by the observation of a dopamine dysregulation syndrome in some patients taking dopaminergic drugs | Moreover, there is increasing evidence that, despite a range of genetic risks for addiction across the population, exposure to sufficiently high doses of a drug for long periods of time can transform someone who has relatively lower genetic loading into an addict |
As described for food reward, sexual experience can also lead to activation of plasticity-related signaling cascades.
4Addiction: A term used to indicate the most severe, chronic stage of substance-use disorder, in which there is a substantial loss of self-control, as indicated by compulsive drug taking despite the desire to stop taking the drug | US Department of Health and Human Services |
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Office of the Surgeon General | , 2008; Pitchers et al |
Angres DH, Bettinardi-Angres K October 2008.